Jeffrey Tambor has quit Transparent in the wake of allegations he sexually harassed other people involved with the hit show.
The 73-year-old strongly denies the accusations and is hitting out at others involved in the production for "politicising" things.
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Tambor says playing the role was one of the greatest privileges of his life - but is now quitting it.
"What has become clear over the past weeks is that this is no longer the job I signed up for four years ago," Tambor said in a statement.
"Given the politicised atmosphere that seems to have afflicted our set, I don't see how I can return to Transparent."
The acclaimed Amazon Video show centres on an American family following the discovery that the person they knew as their father played by Tambor - is transgender.
He has won Emmys and a Golden Globe for the role.
Of the sexual harassment claims, Tambor asserts he didn't intentionally hurt anyone.
"I've already made clear my deep regret if any action of mine was ever misinterpreted by anyone as being aggressive, but the idea that I would deliberately harass anyone is simply and utterly untrue."
The fourth season of Transparent was released in September.
Newshub.