The Public Service Association said the cuts would make the lives of children and young people worse.
Protests are happening in centres across the country on Saturday.
More than 600 jobs are planned to or have got the axe at the ministry.
The Ministry of Social Development is just one department that's owed billions in loans.
The agency's job cut proposals would take its total job losses to 183.
"We have a science system now where there is nobody who is safe."
It had been asked to find savings of 6.5 percent.
The section includes Te Tiriti o Waitangi obligations.
The independent review said there were areas the Department of Internal Affairs could have managed better.
