Hillary Clinton celebrated a "new page for America" on Sunday after Democrat candidate Joe Biden defeated Trump to become the next US President.
Biden flipped the key battleground state of Pennsylvania Sunday morning (local time), its 20 electoral college votes pushing the Democrats over the 270 mark - securing them a win.
"The voters have spoken," Clinton tweeted at 5:51am on Sunday (local time).
"They have chosen Joe Biden and Kamala Harris.
"It's a history-making ticket, a repudiation of Trump, and a new page for America.
"Thank you to everyone who helped make this happen. Onward, together."
The former presidential candidate's message comes four years after she was defeated by current US President Donald Trump.
In 2016, Trump defeated Clinton by 306 to 232 electoral college votes after winning the key battleground states of Wisconsin, Pennsylvania and Michigan.
Clinton won the popular vote by 3 million ballots but was unable to secure the electoral votes required to win the White House.
Her husband, former US President Bill Clinton, tweeted his congratulations to Biden and Harris on the "momentous victory".
"America has spoken and democracy has won," he said.
"Now we have a President-elect and Vice-President-elect who will serve all of us and bring us all together."
US Senator Bernie Sanders also congratulated Biden and Harris for their historic win during an "incredibly difficult moment in American history".
"I wish them the best as they attempt to bring our nation together around an agenda of economic, social, racial and environmental justice," Sanders tweeted.
Clinton is now one of the 538 electors in the electoral college, acting as one of New York's 29 delegates.
"I'm an elector in New York," Clinton told SiriusXM. "I'm sure I'll get to vote for Joe [Biden] and [Harris] in New York. So, that's pretty exciting."