Jools and Lynda Topp say they "are fighters, always have been, always will be" and will attend a 40th anniversary tribute concert in Auckland in November.
Tickets for the A Topp Twins 40th Anniversary Tribute Concert have gone on sale on Friday.
The event at Auckland's Civic Theatre will take place on Monday, November 7.
The line-up of artists performing at the tribute concert include Tami Neilson, Anika Moa, Ria Hall, Dame Hinewehi Mohi, Troy Kingi, Jackie Clarke, Annie Crummer and Don McGlashan.
Each of the acts will perform Topp Twins' songs "with a twist", while some of New Zealand's funniest comedians, as well as special guests, will pay homage to the godmothers of the local comedy scene.
The concert will be hosted by Karen O'Leary, Dame Lynda's on-screen daughter in Wellington Paranormal.
The Topp Twins posted on Facebook that they will be attending.
"Jools & I will be there to perform with our friends. We are fighters, always have been, always will be. See ya there," they said.
The concert will be their first public performance since Lynda's cancer diagnosis and COVID-19 lockdowns halted their plans for a national tour in 2022 to celebrate their 40th anniversary as performers.
Proceeds from the concert will help pay for the twins' ongoing treatment and living costs.
The concert was announced on the same day it was revealed Lynda Topp had been forced to stop chemotherapy for her breast cancer, due to a "nerve damaging side effect".
An update on the Topp Twins Facebook on Friday revealed that they're trying to "stay positive everyday".
"Lynda has had to stop her chemo treatment due to chemo induced peripheral neuropathy which is a nerve damaging side effect of the weekly chemo she was receiving," the statement said.
"Symptoms are tingling, pain, numbness and reduced balance in her feet. She is currently receiving acupuncture treatment and natural plant based remedies as there is no known cure for this."